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Cancer poses a significant threat to life, making early diagnosis and prompt treatment critical for enhancing survival rates. Conventional detection methods can be slow and often lack the necessary sensitivity to catch the disease in its early stages. This book explores cutting-edge biomarker detection strategies, including nanosensors, nucleic acid-based aptamers, nanowires, quantum dots, and nanoclusters. Innovations like the Surface Plasmon Resonance mechanism for early cancer detection, along with breakthroughs in cancer biosensing for point-of-care diagnostics, are transforming the landscape of cancer detection and improving outcomes significantly.